NAME
Ritsuko Komaki, MD

Professor of Radiation Oncology

EDUCATION/TRAINING

Hiroshima University, Hiroshima, Japan B.S. 1965 Biology
Hiroshima University School of Medicine, Hiroshima M.D. 1969 Medicine
Medical College of Wisconsin, Milwaukee, WI Resident 1977 Radiation Oncology
Medical College of Wisconsin, Milwaukee, WI Fellowship 1978 Radiation Oncology

A. Positions and Honors.
1998 - 2005 Gloria Lupton Tennison Professorships in Lung Cancer Research
2005 – Pres Gloria Lupton Tennison Distinguished Professorship in Lung Cancer
1978-1983 Assistant Professor, Radiation Oncology, Medical College of Wisconsin
1983-1985 Associate Professor, Radiation Oncology, Medical College of Wisconsin
1985-1988 Associate Professor, Radiation Oncology, Columbia Presbyterian University
1988-1994 Associate Professor, Radiotherapy, UT M.D. Anderson Cancer Center
1994 – Pres Professor of Radiation Oncology (Tenured), UTM. D. Anderson Cancer Center
1979 - Pres Co-Chair, Lung Committee, Radiation Therapy Oncology Group
1984 - Pres NCI: PDQ Extramural Board of Associate Editor Selected
1995 - Pres ABR Oral Board Examiner (Lung, Mediastinum, Soft Tissue & Bone)
1997 - Pres PI for UTM. D. Anderson Cancer Center for RTOG
1999 - 2002 Chair, ASTRO Education Committee
1999 - 2003 US Program Coordinators (President) of Japanese/US Cancer Treatment
Symposium (JUCTS)
2000 - 2006 Council Members - National Council on Radiation Protection and Measurements
2007 – Pres Section Chief, Thoracic Radiation Oncology, UT M.D. Anderson Cancer Center
Honors
1989 Fellow of the American College of Radiology (FACR)
1997 AAWR Research and Education Foundation’s Professional Leadership Award
1994-1997 US New & World Report “Best Doctors in America”
1999 Good Housekeeping Top 318 Cancer Doctors for Women
2003-Pres America’s Top Doctors
2003-Pres Board of Directors, International Association for Study of Lung Cancer (IASLC)
2005 Business and Professional Women of Texas’ BPW/Texas Award
2005 AAWR Marie Sklodowska-Curie Award
2006 Medical College of Wisconsin Alumni of the Year
2006 Fellow of ASTRO, American Society for Therapeutic Radiology and Oncology

B. Selected from 239 peer-reviewed publications (in chronological order)

1. Wang KL, Yang Q, Cleary KR, Swisher SG, Correa AM, Komaki R, Ajani JA, Rashid A, Hamilton SR, Wu TT. The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation. Cancer 107:1786-92, 2006.
2. Sims-Mourtada J, Izzo JG, Apisarnthanarax S, Wu TT, Malhotra U, Luthra R, Liao Z, Komaki R, van der Kogel A, Ajani J, Chao KS. Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res 12:6565-72, 11/2006.
3. Gayed IW, Liu HH, Yusuf SW, Komaki R, Wei X, Wang X, Chang JY, Swafford J, Broemeling L, Liao Z.. The prevalence of myocardial ischemia after concurrent chemoradiation therapy as detected by gated myocardial perfusion imaging in patients with esophageal cancer. J Nucl Med 47:1756-62, 2006.
4. Wang S, Liao Z, Wei X, Liu HH, Tucker SL, Hu CS, Mohan R, Cox JD, Komaki R. Analysis of clinical and dosimetric factors associated with treatment-related pneumonitis (TRP) in patients with non-small-cell lung cancer (NSCLC) treated with concurrent chemotherapy and three-dimensional conformal radiotherapy (3D-CRT).. Int J Radiat Oncol Biol Phys 66:1399-407, 2006.
5. Klopp A, Eapen G, Komaki R. Endobronchial Brachytherapy: An Effective Option for Palliation of Malignant Bronchial Obstruction. Clin Lung Cancer 8:203-207, 2006.
6. Erasmus JJ, Munden RF, Truong MT, Ho JJ, Hofstetter WL, Macapinlac HA, Correa AM, Wu T, Bruzzi JF, Marom EM, Sabloff BS, Ajani JA, Komaki R, Liao Z, Lee JH, Fukami N, Bresalier R, Swisher S. Pre-Operative Chemoradiation –Induced Ulceration in Patients with Esophageal Cancer: A Confounding Factor in Tumor Response Assessment in Integrated CT-PET Imaging. J Thor Oncol 1:478-486, 2006.
7. Bruzzi JF, Swisher SG, Truong MT, Munden RF, Hofstetter WL, Macapinlac HA, Correa AM, Mawlawi O, Ajani JA, Komaki RR, Fukami N, Erasmus JJ. Detection of interval distant metastases: clinical utility of integrated CT-PET imaging in patients with esophageal carcinoma after neoadjuvant therapy.. Cancer 109:125-34, 2007.
8. Erasmus JJ, Munden RF, Truong MT, Ho JJ, Hofstetter WL, Correa A, Macapinlac HA, Ajani J, Komaki R, Liao Z, Lee JH, Bresalier R, Wu T, Swisher SG. Neoadjuvant Therapy-Induced Ulceration in Patients with Esophageal Cancer: A Confounding Factor in Tumor Response Assessment in Integrated CT-PET Imaging. Cancer 109:125 - 134, 2007.
9. Gao XS, Qiao X, Wu F, Cao L, Meng X, Dong Z, Wang X, Gao G, Wu TT, Komaki R, Chang JY. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma. Int J Radiat Oncol Biol Phys 67:389-96, 2007.
10. Wu W, Onn A, Isobe T, Itasaka S, Langley RR, Shitani T, Shibuya K, Komaki R, Ryan AJ, Fidler IJ, Herbst RS, O'reilly MS.. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. Mol Cancer Ther 6:471-83, 2007.
11. Kang Y, Zhang X, Chang JY, Wang H, Wei X, Liao Z, Komaki R, Cox JD, Balter PA, Liu H, Zhu XR, Mohan R, Dong L.. 4D Proton treatment planning strategy for mobile lung tumors.. Int J Radiat Oncol Biol Phys 67:906-14, 2007.
12. Itasaka S, Komaki R, Herbst RS, Shibuya K, Shintani T, Hunter NR, Onn A, Bucana CD, Milas L, Ang KK, O'reilly MS. Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice.. Int J Radiat Oncol Biol Phys 67:870-8, 2007.
13. Guerrero T, Castillo R, Noyola-Martinez J, Torres M, Zhou X, Guerra R, Cody D, Komaki R, Travis E. Reduction of pulmonary compliance found with high-resolution computed tomography in irradiated mice.. Int J Radiat Oncol Biol Phys. 67:879-87, 2007.

C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant) in the research project. Do not list award amounts or percent effort in projects.

ACTIVE

U10CA 105409 01 (Lippman) 07/26/04-12/31/09 1%
$162,000 ($740,720)
NCI/ Full Member Application Affiliated with SWOG

W81XWH-05-2-0027 (Meyn) 02/01/05-03-01-09 10%
DOD $243,890 (Project 3)
Project Co-Leader
IMPACT: Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular argets, Complementary/innovative Treatments, and Therapeutic Modalities.
The major goals of this project is o explore new therapeutic approaches using molecular targets in patients with lung cancer n both preclinical and clinical studies

S/C U10 CA21661 (Curran) 02/01/79-12/31/07 14%
DHHS – NCI $ 180,000 ($48,600,000)
Radiation Therapy Oncology Group (RTOG)
The major goals of the project are to carry out clinical trials in a cooperative group setting

CS2003-8789 7/1/03-7/31/07 4%
NCCN $100,000 ($100,000)
A Phase I Study of Concurrent Carboplatin/Paclitaxel and Celecoxib with Radiation Therapy
for Patients with Unrestable NSCLC