An Expert Panel Forum for a Multicenter Trial on

Stereotactic Body Radiation Therapy (SBRT) vs Surgical Resection in Patients with Operable Stage I Non-Small Cell Lung Cancer

 (Invited participants only)

University of Michigan Medical School, Ann Arbor, Michigan, June 8-9, 2010

7:30 AM                      Breakfast

4302B Med Sci I

Med School

Dean’s Conference Room

7:45 AM                      Why are we here? (SBRT in Lung Cancer: Strategy, Efficacy, Toxicity and Clinical Trials) 

Feng-Ming (Spring) Kong, M.D., Ph.D.

Radiation Oncology, University of Michigan/Ann Arbor VA Hospital, Ann Arbor, Michigan, U.S.A.

Participant self introduction: Participant Profile          

7:55 AM                      Welcome greeting

                                    Mark Orringer, M.D.

Thoracic Surgery, Thoracic Oncology Program, University of Michigan, Ann Arbor, Michigan, U.S.A.

James Hayman, M.D.

Radiation Oncology, University of Michigan, Ann Arbor, Michigan, U.S.A.

8:00 AM                      A concept on a multicenter phase II/III clinical trial to compare SBRT vs. surgery Presentation

Feng-Ming (Spring) Kong, M.D., Ph.D.

Radiation Oncology, University of Michigan/Ann Arbor VA Hospital, Ann Arbor, Michigan, U.S.A.

JinmingYu, M.D., Ph.D.

Radiation Oncology, Shandong Cancer Center, Jinan, Shandong, China

8:30 AM                      FDG-PET in clinical stage 1 NSCLC: What is the possibility of pathologic N+ disease for a PET staged T1N0 disease?  Presentation

                                    Kirk Frey, M.D., Ph.D., Richard Brown, M.D.

                                    Nuclear medicine, University of Michigan, Ann Arbor, Michigan, U.S.A.

8:45 AM                      Treatment options for stage I NSCLC from a pulmonologist: Is SBRT an acceptable option under a clinical trial? What are the potential roles of a pulmonologist for patients treated with SBRT vs surgery? Presentation

Doug Arenberg, M.D.

University of Michigan, Ann Arbor, Michigan, U.S.A.

Mike Simoff, M.D.

 Henry Ford Hospital, Detroit, Michigan, U.S.A.

Chunxue Bai/Jie Hu/Qunying Hong, M.D., Ph.D

Zhongshan Hospital, Fudan University, Shanghai, China

Shun Lu, M.D.

Lung Cancer Center, Chest Hospital, Jiaotong University, Shanghai, China

Jeff Curtis, M.D./ Paul Christensen, M.D.

University of Michigan/Ann Arbor VA Pulmonary Service, Ann Arbor, Michigan, U.S.A.

9:15 AM                      Treatment outcome of surgery in stage I non-small cell lung cancer in China Presentation

Yilong Wu, M.D. (Call in)

Center for Lung Cancer, Guangdong People’s Hospital, Guanzhou, Guandong, China

WeiMing Mao, M.D.

Zhejiang Cancer Center, Hanzhou, Zhejiang, China

Dr. Joseph Kolars, Senior Associate Dean of UM Medical School, came in the conference room to welcome the group, after Dean’s morning conference, before going to his clinic.

Masahiro Hiraoka, M.D. (Call in)                               

Radiation Oncology, Kyoto University Medical School, Kyoto, Japan

9:45 AM                      SBRT in operable cases from RTOG: Challenges and promises Presentation  
           

Bob Timmerman, M.D. (Call in)                      

Radiation Oncology, University of Texas Southwestern

Medical Center, Texas, U.S.A.

10:15 AM                    Lessons learned from STARs trial (Cyberknife SBRT study) Presentation

Joe Chang M.D., Ph.D.  (Call in)

                                    MD Anderson Cancer Center, Houston, Texas, U.S.A.

Experience in participating STARs trial (Cyberknife SBRT study) Presentation

Bill Loo, M.D. (Call in),
Stanford University Medical School,
Palo Alto, California, U.S.A.

10:30 AM                    SBRT in operable cases: European Experience (ROSEL) Presentation

Suresh Senan, M.D.

Radiation Oncology, VU University Medical Center, Amsterdam, the Netherlands

10: 45AM                    SBRT experience from China: What fractionation regimen should we use? Presentation1 Presentation3

Xiaolong Fu, M.D., Ph.D.

Radiation Oncology, Shanghai Cancer Hospital, Fudan University, Shanghai, China

Luhua Wang M.D.

Radiation Oncology, Peking Union Medical College/Cancer Hospital, Qinhua University, Beijing, China

You Lu, M.D.

Radiation Oncology, West China University Cancer Center, Shichun,

China

11:15 AM                    Fundamental issues in SBRT planning

Target consideration for SBRT: Pathology and Image Correlates Presentation

Jinming Yu, M.D., Ph.D.

Shangdong Cancer Hospital, Jinan, Shandong, China

Impact of Radiation Dose Computation Algorithm on SBRT outcome Presentation

Indrin Chetty Ph.D./ Munther Aljounier, M.D.

Henry Ford Hospital, Detroit, Michigan, U.S.A.

Optimizing IGRT for SBRT

Scott Hadley Ph.D./Martha Matuszak, Ph.D./Jianyue Jin, Ph.D.

University of Michigan and Henry Ford Hospital, Michigan, U.S.A.

11:45 AM                    Any Role of Systemic Therapy/Target Therapy in Early Stage NSCLC?

Kemp Cease, M.D.

Medical Oncology, University of Michigan/Ann Arbor VA Hospital, Ann Arbor, Michigan, U.S.A.

Shun Lu, M.D.

Lung Cancer Center, Chest Hospital, Jiaotong University, Shanghai, China

Chunxue Bai/Jie Hu, M.D., Ph.D.

Department of respiratory disease

 Zhongshang Hospital, Fudan University, Shanghai, China

12:00 Noon                  Lunch

                                    Welcome Lunch from Medical School of University of Michigan

Amy Huang (on behalf of Joseph Kolars) had the lunch with the group.

                                    James O. Woolliscroft, M.D., Dean of University of Michigan Medical School, welcomed the group and shaked hands with individual participants.

1: 00 PM                      CT presentation of local regional failure for NSCLC Presentation

                                    Leslie Quint, M.D.

Thoracic Radiology, University of Michigan, Ann Arbor, Michigan, U.S.A.

1:15 PM                       Quality of life consideration in NSCLC

Benjamin Movsas, M.D.

                                    Radiation Oncology, Henry Ford Hospital, Detroit, Michigan, U.S.A.

1:45 PM                       QA for SBRT in European: ROSEL experience Presentation

Coen Hurkmans, Ph.D. (Call in)

                                    Catharina Hospital, Eindhoven, The Netherlands

2:00 PM                       QA for SBRT of STARS experience

Dong Lei, Ph.D. (Call in)/Peter Balter Ph.D.(Call in)

MD Anderson Cancer Center, Houston, U.S.A.

2:15 PM                       QA and Credentials for SBRT across the Countries Presentation Presentation2

Fang-Fang Yin, Ph.D. Duke University Medical School, Durham, North Carolina, U.S.A.

Ying Xiao, Ph.D. (RTOG experience, Call in)

Thomas Jefferson Hospital, Philadelphia, Pennsylvania, U.S.A.

Ning Jeff Yue, Ph.D. (administrative coordination, Call in)

The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, New Jersey, U.S.A.

2:45 PM                       SBRT experience in some U.S. Institutions: indications and fractionations Presentation

Fractionation considerations Presentation
Jianyue Jin, Ph.D. / Munther Aljuonier, M.D., Henry Ford Hospital, Detroit, U.S.A.

Randall Ten Haken Ph.D./James Balter, Ph.D. /Jean Moran, Ph.D. (Call in), Scott Hadley, Ph.D./ Martha Matuszak, Ph.D.,/Feng-Ming Kong M.D., Ph.D.

University of Michigan, Ann Arbor, Michigan, U.S.A.

                                    Bo Lu, M.D., Ph.D.

Radiation Oncology, University of Vanderbilt Medical Center, Nashville, Tennessee, U.S.A.

Zhongxing Liao, M.D. (Call in)

                                    MD Anderson Cancer Center, Houston, Texas, U.S.A.

                                    Allen Li, Ph.D. (Call in)

                                    Wisconsin Medical College, Wisconsin, U.S.A.

Ping Xia, Ph.D. (Call in)

Cleveland Clinic, Cleveland, Ohio, U.S.A.

Bill Loo, M.D. (Call in), Stanford Medical School, Palo Alto, California, U.S.A.

Ying Hitchcock, M.D. (Call in)

Huntsman Cancer Center, University of Utah, Salt Lake, U.S.A.

Ken Zhen, M.D. (Call in)

University of Nebraska Medical Center, Omaha, Nebraska, U.S.A.

3:00 PM                       Consideration of Biobanking and Correlative Study in China Presentation1

Luhua Wang, M.D.

Peking Union Medical College, Qinhua University, Beijing, China, China

ChunXue Bai, M.D.

Zhongshang Hospital, Fudan University, Shanghai, China

3:30 PM                       Demonstration of SBRT Plans and IGRT at University of Michigan

Scott Hadley, Ph.D., and Martha Matuszek, Ph.D.

4:30PM                        Dinner (American Family Style)

Homes of JJ, Spring, Chris and Sue at 1691 and 1693 Stonebridge, Ann Arbor, Michigan 48108, U.S.A.

*Featured with live music, American Jazz Quartet, by Robert Brickley*

Avraham Eisbruch, M.D., from Radiation Oncology of University of Michigan, greeted the group during the party.

7:00 AM                      Breakfast 

7:15 AM                      Welcome Greeting

Theodore S Lawrence, M.D., Ph.D., Radiation Oncology, University of Michigan, Ann Arbor, Michigan, U.S.A.

Gregory P. Kalemkerian, M.D.

Medical Oncology, Internal Medicine, University of Michigan, Ann Arbor, U.S.A.

7:30 AM                      Challenges and promises of running randomized trial in radiation oncology in China: What is feasible?

                                    Luhua Wang M.D.

Peking Union Medical College/Cancer Hospital, Qinhua University,

Beijing, China,

Xiaolong Fu, M.D., Ph.D.

Shanghai Cancer Hospital, Fudan University, Shanghai, China

You Lu, M.D.

West China University Cancer Center, Shichun, China

7:45 AM                      Results of surgery and quality assurance for surgery in the United States Presentation1 Presentation2

Harvey Pass, M.D.

Thoracic Surgery, New York University, New York, U.S.A.

Andrew Chang, M.D.

                                    Thoracic Surgery, University of Michigan, Ann Arbor, U.S.A.

8:30 AM                      Surgery QA in China & Challenges and promises of running randomized trial in China: Successful experience of IPASS study (Mok, Wu et al, NEJM, 2009) Presentation

Yilong Wu, M.D. (Call in)

Thoracic Surgery, Center for Lung Cancer, Guangdong People’s Hospital, Guanzhou, Guandong, China

8:45 AM                      Final consideration of phase II/III trial on stage I/II NSCLC: Study design and data standardization

                                    Sally Hunsberger Ph.D. (Call in), National Cancer Institute/National Institute of Health, Bethesda, Maryland, U.S.A.

                                    Matt Schipper, Ph.D. University of Michigan, Ann Arbor, Michigan, U.S.A.

                                    Jinming Yu, M.D., Ph.D.

 Shandong Cancer Center, Jinan, Shandong, China

Feng-Ming (Spring) Kong, M.D., Ph.D.

University of Michigan, Ann Arbor, Michigan, U.S.A.

9:15AM                       PET assessment of treatment response and local regional failure for NSCLC Presentation

                                    Kirk Frey, M.D. Ph.D./Feng-Ming Kong, M.D., Ph.D.

                                    University of Michigan, Ann Arbor, Michigan, U.S.A.

11:00 AM                    Touring the University of Michigan

Department of Radiation Oncology, Cancer Center, and Medical School, Central/North Campus

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